💊Enclomiphene Pills | 25mg X 100

Enclomiphene, the trans-isomer of Clomiphene, is a nonsteroidal selective estrogen receptor modulator (SERM) with a distinct mechanism of action targeting the hypothalamic-pituitary-gonadal (HPG) axis. It functions as an estrogen receptor antagonist in the hypothalamus, preventing negative feedback inhibition and increasing gonadotropin-releasing hormone (GnRH) pulsatility. This leads to elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion from the anterior pituitary, thereby stimulating endogenous testosterone production through Leydig cell activation. Enclomiphene primarily engages the estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), with its antagonistic effects localized in the central nervous system while exhibiting minimal peripheral estrogenic activity. 

Additionally, it modulates the cyclic AMP-protein kinase A (cAMP-PKA) pathway and interacts with steroidogenic acute regulatory protein (StAR) expression, further enhancing steroidogenesis. Unlike its cis-isomer, zuclomiphene, which exhibits mixed agonist-antagonist effects, enclomiphene maintains a more selective profile favoring anti-estrogenic activity. Its pharmacokinetic properties include a moderate half-life and hepatic metabolism via cytochrome P450 enzymes, leading to biotransformation into active metabolites that prolong its physiological effects. Through precise receptor modulation and endocrine signaling, Enclomiphene represents a targeted approach for HPG axis stimulation in preclinical and laboratory research.