Epithalon (also known as Epitalon, Epithalone or Epithalamin) is a short synthetic peptide known to activate the telomerase enzyme and stimulate melatonin release. First developed in Russia in the 1980s, epithalon has been shown to delay age-related changes in reproductive and immune systems and increase the life span of mice and rats. Though it is primarily of interest in anti-aging research, epithalon has shown significant effects in certain types of cancer, infectious disease, and in DNA regulation.

 

Epithalon Research

1. The Role of Telomerase in the Anti-Aging Effects of Epithalon

Early research using insects and rodents revealed that epithalon can prolong life substantially. In normal, healthy fruit flies and rats, epithalon decreases mortality by 52%. In mice prone to both heart disease and cancer, epithalon prolongs life by as much as 27% compared to controls[1]. At least part of the answer to how epithalon achieves these profound effects is via its elimination of free radicals (charged molecules that do damage to healthy tissue).

Anti-oxidant activity is not the only reason that epithalon extends life, however. There is good evidence from in vitro experiments on human somatic cells to show that epithalon activates an enzyme called telomerase [2]. Telomerase protects telomeres, the ends of chromosomes that are critical to ensuring the health of DNA. Epithalon’s activation of telomerase leads directly to a decrease in how many errors a strand of DNA contains, supporting the notion that epithalon protects DNA from damage [3], [4]. In short, epithalon protects DNA from accumulating errors over time, a process that eventually leads to cell dysfunction, aging, and even cancer in some cases.

2. Epithalon and DNA Activation

Neither its impact on free radicals nor its effects on telomeres seem sufficient to explain the profound effects that epithalon has on longevity. Indeed, scientists are working hard to understand how this short peptide achieves the effects that it does so that the mechanisms can be explored in depth. As it turns out, at least part of the answer may come from the fact that epithalon changes the expression of certain genes.

Research in cell cultures shows that epithalon interacts directly with DNA to turn on and enhance the expression of certain genes. Epithalon interacts with the promoter regions of genes for CD5, IL-2, MMP2, and Tram1 [5]. CD5 and IL-2 both affect the function of the immune system while MMP2 plays a critical role in the maintenance of extracellular matrix in skin, tendons, and other connective tissue. These findings suggest that epithalon may impact the function of the immune system and the ability of the body to heal itself following not only injury, but following typical day-to-day stress as well.

It is not surprising that epithalon impacts the immune system. Research in rats indicates that epithalon boost the expression of interferon gamma in aging lymphocytes[0]. Interferon gamma is a critical signaling molecule in the immune system. It is important for fighting off viral infections through the activation of macrophages, natural killer cells, and T cells.

3. Epithalon and Skin Health

As stated above, epithalon has a positive effect on the gene that regulates MMP2. MMP2 is a protein found in connective tissue like skin. Research in rodents indicates that not only does epithalon activate this gene, it activates fibroblasts, the cells that produce and maintain MMP2 as well as other components of the extracellular matrix like collagen and elastin. Mice exposed to epithalon show an increase in fibroblast activation of 30-45%[7]. By activating fibroblasts, epithalon can help to boost rates of healing and offset the natural decline in skin structure and integrity that occurs with aging.

Further evidence for epithalon’s benefit in skin comes from the fact that it decreases caspase-3 activity. Caspase-3 is an enzyme in the apoptosis or programmed cell death pathway. By decreasing caspase-3 activity, epithalon helps to protect fibroblasts and other skin cells, keeping them alive and healthy for longer periods of time[8].

4. Epithalon and Tumor Growth

Daily administration of epithalon to rats with cancer has been found to decrease tumor growth[]. Not only does the peptide reduce tumor growth, it prevents the metastasis or spread of these tumors to distant tissues as well [10], [11]. Epithalon is currently being investigated as a potential treatment for Her-2/neu positive breast cancers and is of interest in preventing the development of certain types of leukemia as well as testicular cancer

5. Epithalon and Melatonin Secretion

Melatonin, which is linked to sleep and aging, is produced by the pineal gland. Research in rats shows that epithalon and similar peptides affect both the synthesis and release of melatonin by affecting the expression of two proteins (arylalkylamine-N-acetyltransferase (AANAT) and pCREB transcription protein) [15]. Both of these genes play an important role in melatonin production and in the circadian (day/night) control of melatonin release. Research in monkeys indicates that epithalon restores melatonin secretion to normal [16].

6. Epithalon and Eyesight

A trial in rats suffering from retinitis pigmentosa found that epithalon improves outcomes in 90% of patients[17]. It appears that the peptide helps to preserver normal structure of the eye while boosting the bioelectric function of the retina necessary for vision.

Epithalon exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Epithalon for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Epithalon if you are a licensed researcher.

Epithalon (Epitalon) FAQs – Dosage, Benefits & Safety

1. What is Epithalon (Epitalon)?

Epithalon is a synthetic peptide composed of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. It is derived from epithalamin, a natural peptide produced in the pineal gland. Epithalon is primarily studied for its potential anti-aging effects, promoting longevity, enhancing immune function, and improving overall well-being .

2. How does Epithalon work?

Epithalon is believed to work by stimulating the production of telomerase, an enzyme that helps maintain the length of telomeres—protective caps at the ends of chromosomes. By preserving telomere length, Epithalon may help slow down cellular aging and promote longevity. Additionally, it may regulate the production of melatonin, supporting better sleep quality .

3. What are the potential benefits of Epithalon?

• Anti-Aging: May help slow down the aging process by preserving telomere length.

• Improved Sleep: Supports the regulation of melatonin, leading to better sleep quality.

• Enhanced Immune Function: Potentially boosts the immune system, helping the body fend off illnesses.

• Increased Energy Levels: May contribute to higher energy and reduced fatigue.

• Skin Health: Could promote healthier, more youthful-looking skin by supporting cellular repair .

4. What are the typical dosages and administration methods?

Epithalon is typically administered via subcutaneous or intramuscular injection. Common dosages include:

• 10 mg per day: Often used for general wellness and maintenance.

• 20 mg per day: May be used for more intensive anti-aging protocols.

• 25 mg per day: Sometimes utilized in clinical settings for specific therapeutic goals.

• 50 mg per day: Higher doses are less common and should only be considered under strict medical supervision.

A common regimen involves daily administration for 10–20 days, followed by a break. This cycle can be repeated multiple times a year, depending on individual goals and healthcare provider recommendations .

5. Is Epithalon safe to use?

Epithalon is generally considered safe when used appropriately. Reported side effects are rare and usually mild, including:

• Temporary fatigue

• Mild headaches

• Dizziness

• Injection site reactions (redness or swelling)

However, due to limited long-term studies, it’s essential to consult with a healthcare professional before starting Epithalon therapy, especially for individuals with existing medical conditions or those taking other medications .

6. Can Epithalon be taken orally?

While Epithalon is primarily administered via injection due to its peptide nature, some oral formulations exist. However, oral bioavailability is significantly lower, and the effectiveness of oral Epithalon is not well-established. Sublingual (under the tongue) administration may offer better absorption than traditional oral ingestion .

7. Is Epithalon approved by regulatory authorities?

As of now, Epithalon is not approved by major regulatory bodies like the U.S. Food and Drug Administration (FDA) for any specific medical condition. It is primarily available through research suppliers and compounding pharmacies. Regulations may vary by country, so it’s crucial to consult local laws and a healthcare professional before considering its use .

8. Can Epithalon be combined with other therapies?

Yes, Epithalon is often used alongside other anti-aging treatments, such as:

• Thymosin Alpha-1: Enhances immune function.

• GHK-Cu: Promotes tissue repair and regeneration.

• BPC-157: Supports healing and recovery.

Combining Epithalon with other peptides or supplements may enhance overall benefits, but such combinations should always be supervised by a healthcare provider to ensure safety and efficacy .

9. How quickly can I expect to see results?

Results from Epithalon therapy can vary based on individual factors such as age, health status, and dosage. Some users report improvements in sleep quality and energy levels within a few weeks. More significant anti-aging effects, like enhanced skin health and increased vitality, might take several months of consistent use .

10. How should Epithalon be stored?

Proper storage is crucial to maintain Epithalon’s effectiveness:

• Refrigeration: Store vials in the refrigerator at 2–8°C (36–46°F).

• Protection from Light: Keep the peptide away from direct sunlight.

• Avoid Freezing: Do not freeze, as this may degrade the peptide’s structure.

Always follow the storage guidelines provided by the manufacturer or your healthcare provider .

Disclaimer: This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new supplement or therapy.

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